I've had a few minor issues, I've noticed that I can't export to a PDF from LayOut, I have to print to PDF instead. I've also had some issues that may be unrelated to macOS, like crashing when working with detailed imported DWGs. Upon closer inspection though, the DWG is terrible, very few closed polygons, lots of errant lines, which I why I'm not so sure it's the Beta.
And I get crashes when I try to edit the text on dimensions and labels.
Edit: It would appear I get crashes when I attempt to make new labels, maybe something about the autosuggest label feature? It doesn't happen when I make a label that isn't attached to anything.