This is super annoying and wastes my time.
It happens maybe once a week.
Randomly Layout will, blink is the best way to describe it, and the floating custom trays that I have laboriously set up are deleted and reset to the Default Tray which is docked.
I’m on latest Layout version.
The tray system in Layout is generally a bit wanting. It seems (for me) that any tray that is wider than 599 pixels gets reset to 300px if it is moved or when you start a new Layout session.