I was last working on Version 381.65 - and the upgrade to 381.89 broke Pronterface, my TrackIR gui and SketchUp.
Steps to fix before downgrading the video driver included looking to see if I could reverse the creators update, an anti-spyware scan (just in case, nothing found), and I even reinstalled the affected applications after trying the compatibility troubleshooting wizards. The application logs were entirely useless as well - said there was a crash, but had no codes or anything special to help dig deeper.
After everything else failed, I installed the 381.65 driver - and I removed support for VR in the process (using custom install), and did a clean installation.
Everything is back to normal.