Using the ctrl, shift and alt modifier keys begins to add varying levels of finger / thumb contortions and you’ll have to use a second hand for many.
I use AutoHotKey to increase the number of easier shortcut key combinations available to me that replace combinations such as ctrl + shift and especially ctrl + shift + alt.
So, I can have a single key press as a shortcut but also a quick double tap press and a long press, e.g. a single T press activates Curic’s DIO Trowel tool and a quick double T press activates the native tape measure tool.
I have a custom tag visibility plugin that toggles tags or groups of tags on / off on the fly which I access with space + key, e.g. space + N toggles the existing arrangement with the proposed arrangement, space + W toggles the wall tag, space + 1 toggles only the ground floor on / off.
space + N is actually ctrl + shift + alt + N.
This means that I can do all my fast modelling in just one scene - previously I followed the Brightman method of having various scenes set up for existing, proposed, external walls off and so on… which meant changing scenes frequently while modelling.