As I typed the subject line, I got a popup for similar topics, mostly dating back to 2016. So this is still not resolved . . I downloaded ScrollReverser but that is global and not app specific, which means I need to remember to enable it when I slip into Layout - and to disable when I switch out of it. PITA. I just find it hard to believe this simple option is not being implemented in one form or another.
+1 for rolling in an option to allow SpaceMouse to work the zooming feature, esp. if one could configure a side button to Zoom Extents/Window . .