I think perhaps we could start by asking what country this is in and how they build. People are talking about setbacks and framing, because that matters where they are at, but most of the world doesn’t use setbacks or wooden construction.
In many places cheap fast growing farmed pine is not a thing and clay is abundant and cheap so solid brick is used. It is easy to track to odd profiles of the lot lines when using brick, especially when it won’t be the final show surface itself.
My guess is you are in such a place where you are going to build to lot lines, so you are tied into the angle (and curve on a few of those parcels) of the lot line.
So people responding kind of need to know this so they don’t keep trying to lead you back to 90s and straights, the don’t exist on your lot lines and you are stuck with what those give you. You should try to have a wall be straight where you intend to have doors and windows. When you get to interior rooms, you might consider picking an edge to be either parallel or perpendicular for each room.
Where I’m at you can’t put a window on a lot line unless it is the road access side, if that is the case where you are at this simplifies things because you won’t have windows on walls that are built to the three of your adjacent land sides and therefore follow a curving line on the back.
The front where it looks like you are going to have a walkway set into it anyhow, you are free to make the walls straight at least, if not exactly along one of the set axis. It would be easiest if you could align that front wall to be on a primary axis but if not set your axis for the front face of each building as discussed above and then draw directly on the flat face and you should have no trouble pushing and pulling through.
The thing to watch out for if the land slopes make sure your floor does not and that you base your axes on that floor. I would recommend starting from a file that has no slope shown and do each building from that as its own component. Then you can be sure everything that should run horizonal like window openings does.
Then you can drop each building (as a component) into location on the file that does have the sloping land and set the vertical placement of each one as you see fit. If you have that slope in your house files you can get yourself messed up and once things aren’t staying parallel to the bottom plane it is just going to go downhill (forgive the pun) from there.