For your info, I am using successfully SketchUp with a wacom cintiq pro 16 tablet and a wacom 3D pen - that is the one with 3 buttons - and a space mouse from 3D connexion.
The pen in my right hand for pointing and clicking and context menu clicking. Left hand is for navigation on the space mouse. Highly recommended! It’s fun to swoop around the model so fast. The third pen button gives an alternative for orbit and pan with modifier key - Just like a middle/wheel mouse button.
I operate the small wacom keyboard with either hand, whichever is available. I use keyboard shortcuts a lot. Wacom has many other on-screen operation options, like diverse commands wheels and number pads etc… But I find keyboard shortcuts so much faster.
Sometimes my hand is covering up screen content like the value entering box at the bottom right of the monitor. Then I need to do a bit of wrist gymnastics. Not ideal but a common problem when using a pen in lieu of a mouse.
Layout however still does not support the space mouse, pooop poooop!
I have a sore hand and try to stay away from using a mouse.
Good luck with finding your perfect set up.