You can do either. I would probably split it up into smaller groups/components. The key thing is to create scenes in SketchUp that show what you want to show in a given viewport in LO. In your case you might create a scene for each floor plan in the model. Then select the desired scene for each viewport in LayOut. BTW, you only send the SketchUp file to LayOut once. That creates the first viewport. To get additional viewports, copy an existing one.
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