You’ve locked many of the viewports so they won’t refresh until they are unlocked. If you want to protect the viewports from being modified, first make sure the viewports are on their own layer and then lock the layer instead of locking the viewports. Put entities that you draw in LayOut over the viewports on a separate layer above the viewport layer.
You’ve also modified the camera for some viewports like this one.
If the viewport gets reset the viewport will be screwed up.
Best practice is to avoid modifying the Camera properties in LayOut.
BTW, I would suggest removing the LayOut file since it contains client information.